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Name

Rosiglitazone

Description

Rosiglitazone is an anti-diabetic drug in the thiazolidinedione class of drugs. It is marketed by the pharmaceutical company GlaxoSmithKline as a stand-alone drug (Avandia) and in combination with metformin (Avandamet) or with glimepiride (Avandaryl). Like other thiazolidinediones, the mechanism of action of rosiglitazone is by activation of the intracellular receptor class of the peroxisome proliferator-activated receptors (PPARs), specifically PPARγ. Rosiglitazone is a selective ligand of PPARγ, and has no PPARα-binding action. Apart from its effect on insulin resistance, it appears to have an anti-inflammatory effect: nuclear factor kappa-B (NFκB) levels fall and inhibitor (IκB) levels increase in patients on rosiglitazone. Recent research has suggested that rosiglitazone may also be of benefit to a subset of patients with Alzheimer's disease not expressing the ApoE4 allele. This is the subject of a clinical trial currently underway.

Brands

Werrick

Blutab

Hasan

DH-Rosidia

Elea

Diaben

Farmindustria

Diaglinex

Craveri

Gaudil

Denver

Gliximina

Hisun

Naidi

Torrent

Rogelin

Gedeon Richter

Roglit

Drug International

Romerol

Delta

Rosit

Garmisch

Rosix

Trima

Rossini

Square

Sensulin

Hengrui

Sheng Ao

ShengJiTang Pharmaceutical

Sheng Min